The Research
Independently validated as a “results oriented breakthrough.”
The Science Behind Smarter Delivery
Published in the Journal of Cosmetic Dermatology, a peer-reviewed medical journal, research on SIREN Capsule Technology™ demonstrated statistically significant results across multiple skin parameters, including: ±
• Reduced ROS production associated with oxidative stress*
• Improved skin hydration and support of the skin's moisture barrier**
• Reduced transepidermal water loss (TEWL)**
• Improved skin texture and visibly reduced appearance of fine lines and wrinkles***
Free radicals—scientifically known as reactive oxygen species or ROS—are unstable molecules generated by exposure to UV light, pollution, blue light, and normal cellular metabolism. When free radicals overwhelm the skin’s natural defenses, the result is oxidative stress that can show up as dullness, fine lines, and uneven texture. Skincare actives, like antioxidants, help neutralize free radicals.
Most skincare sits on the surface. Siren Capsule Technology™ is designed to deliver actives deeper, precisely targeting the free radical activity that drives visible signs of aging before they appear.
See Full White Paper
% ROS PRODUCTION
Placebo Formula
NON-ENCAPSULATED VITAMIN C + A FORMULA
SIREN ENCAPSULATED VITAMIN C + A FORMULA
ENCAPSULATED VITAMIN C + A FORMULA
Free radicals—scientifically known as reactive oxygen species or ROS—are unstable molecules generated by exposure to UV light, pollution, blue light, and normal cellular metabolism. When free radicals overwhelm the skin’s natural defenses, the result is oxidative stress that can show up as dullness, fine lines, and uneven texture. Skincare actives, like antioxidants, help neutralize free radicals.
Most skincare sits on the surface. Siren Capsule Technology™ is designed to deliver actives deeper, precisely targeting the free radical activity that drives visible signs of aging before they appear.
See Full White Paper
Disclaimers
±Catalano A, Mitri K, Perugini P, Condrò G, Sands C. J Cosmet Dermatol. 2023;22:3329–3339. doi:10.1111/jocd.16016. Note: Study authors include the patent inventors and patent owner representative.
*Based on an independent in vitro study using oxidative stress-treated human keratinocyte cells (HaCaT), comparing ROS production in SIREN-treated cells (5 mg/mL) versus placebo-treated cells. Results showed statistically significant inhibition of menadione-induced ROS release (p<0.01).
**Based on an independent instrumented study (CM 825 Corneometer; Tewameter TM 300) with 30 healthy female participants aged 36–58, comparing net effect of SIREN-treated skin versus placebo after 4 weeks of daily application.
***Based on an independent in vivo topographical 3D analysis (dermaTOP/Breuckmann OPTOCAT) with 30 participants, measuring percent variation from baseline after 28 days of daily application.